TACFormer: Transformer-Based Generative Model for Target-Conditioned De Novo PROTAC Design

Paper recorded by Signals 4 on 2026-10-29 in cs.LG. Abstract reproduced from arXiv; link to the original below.

Published 2026-10-29 on arXiv · recorded by Signals 4 on 2026-10-30

Category: cs.LG · 机器学习 · first seen 2026-10-30

Abstract

Targeted protein degradation (TPD) represents a fundamental shift in drug discovery, moving beyond traditional target inhibition toward the event-driven removal of disease-causing proteins. A prominent strategy for TPD is the use of proteolysis-targeting chimeras (PROTACs), heterobifunctional molecules that selectively route a protein of interest (POI) to the ubiquitin-proteasome system for degrad

Read on arXiv →